PER2 and CLOCK

Number of citations of the paper that reports this interaction (PubMedID 23555304)
19

Data Source:
BioGRID (two hybrid)

		PER2	CLOCK
Description		period circadian regulator 2	clock circadian regulator
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle CLOCK-BMAL Transcription Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding	DNA Damage Checkpoint Signaling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Acetylation Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Circadian Clock	BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression HATs acetylate histones Circadian Clock Heme signaling
Drugs
Diseases
GWAS		Chronotype ( 26955885 30696823 27494321) Morning vs. evening chronotype ( 26955885 26835600 27494321)	Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Neutrophil percentage of white cells ( 32888494) Personality dimensions ( 18957941) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: BHLHE41 BTRC CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MDM2 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBL4A	27 interacting genes: ARNTL ARNTL2 BHLHE41 CEP135 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B NPAS2 PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1
Entrez ID		8864	9575
HPRD ID		04575	03508
Ensembl ID		ENSG00000132326	ENSG00000134852
Uniprot IDs		O15055	O15516 Q3ZCT4 Q53EU0
PDB IDs		6OF7	4H10 6QPJ
Enriched GO Terms of Interacting Partners?
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