PER2 and TPTEP2-CSNK1E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PER2	TPTEP2-CSNK1E
Description		period circadian regulator 2	TPTEP2-CSNK1E readthrough
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Circadian Clock	WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Circadian Clock Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol AURKA Activation by TPX2
Drugs			Seliciclib
Diseases
GWAS		Chronotype ( 26955885 30696823 27494321) Morning vs. evening chronotype ( 26955885 26835600 27494321)
Interacting Genes		22 interacting genes: BHLHE41 BTRC CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MDM2 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBL4A	4 interacting genes: DVL3 PER2 TRIM3 ZNF618
Entrez ID		8864	102800317
HPRD ID		04575
Ensembl ID		ENSG00000132326	ENSG00000283900
Uniprot IDs		O15055	B3KRV2 P49674 Q5U045
PDB IDs		6OF7	4HNI 4HOK
Enriched GO Terms of Interacting Partners?
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