NR1I2 and MAPK7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NR1I2	MAPK7
Description		nuclear receptor subfamily 1 group I member 2	mitogen-activated protein kinase 7
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Nuclear Body Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Xenobiotic Catabolic Process Xenobiotic Transport Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	MAPK Cascade Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs		Vitamin E Oxiconazole Phenytoin Diethylstilbestrol Clotrimazole Pentobarbital Spironolactone Lindane Flutamide Ritonavir Erlotinib Cyclophosphamide Mephenytoin Carbamazepine Tamoxifen Warfarin Ethotoin Estradiol Mifepristone Methylphenobarbital Ethinylestradiol Ketoconazole Fenofibrate Rifampicin Clonazepam Miconazole Nifedipine Econazole Sulfinpyrazone Phenobarbital Ifosfamide Rifaximin Paclitaxel Dexamethasone Docetaxel Bezafibrate Genistein Prasterone Hyperforin Resveratrol Pregnenolone Quercetin SR12813 Afimoxifene Phenolphthalein Permethrin Dovitinib Chenodeoxycholic acid TO-901317 Hexestrol Triclosan Rilpivirine Pyrethrum extract Myrrh Piperine Troleandomycin Fenofibric acid Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate alpha-Tocopherol succinate D-alpha-Tocopherol acetate Dexamethasone acetate	Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol levels ( 32203549) Lymphocyte percentage of white cells ( 32888494) Total cholesterol levels ( 30275531)	Alzheimer's disease ( 30636644)
Interacting Genes		32 interacting genes: ACTN2 ATP6AP1 CHMP1A DNMT3L DYRK2 EP300 FGR HNF4A MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NR0B2 NR5A2 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBE2I UBR5	37 interacting genes: ACTN4 ADI1 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FLII FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K4 MAP2K5 MEF2A MEF2C MEF2D MFAP4 MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RASGRP1 RXRA SGK1 SH2D2A SREBF1 UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1
Entrez ID		8856	5598
HPRD ID		04346	03952
Ensembl ID		ENSG00000144852	ENSG00000166484
Uniprot IDs		F1D8P9 O75469	A0A024QZ20 Q13164
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS 6DUP 6HJ2 6HTY 6NX1 6P2B 6S41 6TFI 6XP9 7AX8 7AX9 7AXA 7AXB 7AXC 7AXD 7AXE 7AXF 7AXG 7AXH 7AXI 7AXJ 7AXK 7AXL	2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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