NR1I2 and POU1F1

Number of citations of the paper that reports this interaction (PubMedID 11891224)
5

Data Source:
HPRD (in vitro)

		NR1I2	POU1F1
Description		nuclear receptor subfamily 1 group I member 2	POU class 1 homeobox 1
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Nuclear Body Intermediate Filament Cytoskeleton	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Xenobiotic Catabolic Process Xenobiotic Transport Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Adenohypophysis Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs		Vitamin E Oxiconazole Phenytoin Diethylstilbestrol Clotrimazole Pentobarbital Spironolactone Lindane Flutamide Ritonavir Erlotinib Cyclophosphamide Mephenytoin Carbamazepine Tamoxifen Warfarin Ethotoin Estradiol Mifepristone Methylphenobarbital Ethinylestradiol Ketoconazole Fenofibrate Rifampicin Clonazepam Miconazole Nifedipine Econazole Sulfinpyrazone Phenobarbital Ifosfamide Rifaximin Paclitaxel Dexamethasone Docetaxel Bezafibrate Genistein Prasterone Hyperforin Resveratrol Pregnenolone Quercetin SR12813 Afimoxifene Phenolphthalein Permethrin Dovitinib Chenodeoxycholic acid TO-901317 Hexestrol Triclosan Rilpivirine Pyrethrum extract Myrrh Piperine Troleandomycin Fenofibric acid Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate alpha-Tocopherol succinate D-alpha-Tocopherol acetate Dexamethasone acetate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol levels ( 32203549) Lymphocyte percentage of white cells ( 32888494) Total cholesterol levels ( 30275531)	Menarche (age at onset) ( 25231870) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		32 interacting genes: ACTN2 ATP6AP1 CHMP1A DNMT3L DYRK2 EP300 FGR HNF4A MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NR0B2 NR5A2 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBE2I UBR5	22 interacting genes: ARID5A ARSA CREBBP ETS1 GATA2 JUN KRTAP10-8 KRTAP15-1 KRTAP6-1 LASP1 LHX4 MSX2 NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG RAD54L2 UBE2I VDR
Entrez ID		8856	5449
HPRD ID		04346	01409
Ensembl ID		ENSG00000144852	ENSG00000064835
Uniprot IDs		F1D8P9 O75469	P28069
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS 6DUP 6HJ2 6HTY 6NX1 6P2B 6S41 6TFI 6XP9 7AX8 7AX9 7AXA 7AXB 7AXC 7AXD 7AXE 7AXF 7AXG 7AXH 7AXI 7AXJ 7AXK 7AXL	5WC9
Enriched GO Terms of Interacting Partners?
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