MAPK7 and MEF2D

Number of citations of the paper that reports this interaction (PubMedID 10849446)
60

Data Source:
HPRD (in vitro, in vivo)

		MAPK7	MEF2D
Description		mitogen-activated protein kinase 7	myocyte enhancer factor 2D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Adult Heart Development Muscle Organ Development Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling	Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis NGF-stimulated transcription NGF-stimulated transcription Heme signaling
Drugs		Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644)	Body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		37 interacting genes: ACTN4 ADI1 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FLII FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K4 MAP2K5 MEF2A MEF2C MEF2D MFAP4 MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RASGRP1 RXRA SGK1 SH2D2A SREBF1 UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1	24 interacting genes: - APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 DNMT3L EP300 FBXO7 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SKP2 SNCA SP1 YWHAQ
Entrez ID		5598	4209
HPRD ID		03952	02810
Ensembl ID		ENSG00000166484	ENSG00000116604
Uniprot IDs		A0A024QZ20 Q13164	Q14814
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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