TNFRSF10B and TIMM50

Number of citations of the paper that reports this interaction (PubMedID 15044455)
28

Data Source:
BioGRID (two hybrid)

		TNFRSF10B	TIMM50
Description		TNF receptor superfamily member 10b	translocase of inner mitochondrial membrane 50
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Integral Component Of Membrane Nuclear Speck
	Molecular Function	Protein Binding TRAIL Receptor Activity Signaling Receptor Activity TRAIL Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Interleukin-2 Receptor Binding Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus	Release Of Cytochrome C From Mitochondria Protein Dephosphorylation Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Peptidyl-tyrosine Dephosphorylation
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling	Mitochondrial protein import
Drugs		HGS-TR2J Lexatumumab
Diseases
GWAS		Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Renal cell carcinoma ( 28598434)
Interacting Genes		17 interacting genes: ASPH CASP8 CDC42 CFLAR FADD KCNQ3 MADD MUC1 PCM1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15	5 interacting genes: DNM1 LY6E-DT PAFAH1B2 RAF1 TNFRSF10B
Entrez ID		8795	92609
HPRD ID		04680	12118
Ensembl ID		ENSG00000120889	ENSG00000105197
Uniprot IDs		O14763 Q7Z2I8	A0A024R0M6 Q3ZCQ8
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?