TNFRSF10B and TNFSF10

Number of citations of the paper that reports this interaction (PubMedID 9311998)
253

Data Source:
HPRD (in vivo, in vitro)

		TNFRSF10B	TNFSF10
Description		TNF receptor superfamily member 10b	TNF superfamily member 10
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding TRAIL Receptor Activity Signaling Receptor Activity TRAIL Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding TRAIL Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus	Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Male Gonad Development Response To Insulin Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
Drugs		HGS-TR2J Lexatumumab
Diseases
GWAS		Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Renal cell carcinoma ( 28598434)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Liver volume ( 34128465) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		17 interacting genes: ASPH CASP8 CDC42 CFLAR FADD KCNQ3 MADD MUC1 PCM1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15	9 interacting genes: ACP5 CASP3 RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17
Entrez ID		8795	8743
HPRD ID		04680	04670
Ensembl ID		ENSG00000120889	ENSG00000121858
Uniprot IDs		O14763 Q7Z2I8	P50591 Q6IBA9
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J	1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?
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