KCNK5 and MAN2B2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KCNK5	MAN2B2
Description		potassium two pore domain channel subfamily K member 5	mannosidase alpha class 2B member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane	Lysosome Vacuolar Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Voltage-gated Ion Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Leak Channel Activity	Alpha-mannosidase Activity Protein Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Potassium Ion Transport Excretion Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane	Mannose Metabolic Process
Pathways		Phase 4 - resting membrane potential	Lysosomal oligosaccharide catabolism
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483)
Interacting Genes		30 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIF1A YIPF6	9 interacting genes: APPBP2 CISD2 CPLX4 CREB3L1 FKBP7 GPX8 KCNK5 KRTAP3-2 LIME1
Entrez ID		8645	23324
HPRD ID		04604	14355
Ensembl ID		ENSG00000164626	ENSG00000013288
Uniprot IDs		A0A024RD32 A0A0B6VPR3 O95279	B7Z754 E9PCD7 Q9Y2E5
PDB IDs
Enriched GO Terms of Interacting Partners?
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