KCNK5 and FRAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		KCNK5	FRAT1
Description		potassium two pore domain channel subfamily K member 5	FRAT regulator of WNT signaling pathway 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Voltage-gated Ion Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Leak Channel Activity	Protein Binding
	Biological Process	Potassium Ion Transport Excretion Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane	Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Phase 4 - resting membrane potential	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)	Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte counts ( 32888494) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIF1A YIPF6	13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7
Entrez ID		8645	10023
HPRD ID		04604	03935
Ensembl ID		ENSG00000164626	ENSG00000165879
Uniprot IDs		A0A024RD32 A0A0B6VPR3 O95279	Q92837
PDB IDs			1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?
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