DEGS1 and C4orf3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		DEGS1	C4orf3
Description		delta 4-desaturase, sphingolipid 1	chromosome 4 open reading frame 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Sphingolipid Delta-4 Desaturase Activity Retinol Isomerase Activity
	Biological Process	Unsaturated Fatty Acid Biosynthetic Process Electron Transport Chain Sphingolipid Biosynthetic Process Myelin Maintenance Ceramide Biosynthetic Process	Negative Regulation Of Calcium Ion Binding Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Blood protein levels ( 28240269)
Interacting Genes		5 interacting genes: C4orf3 DISC1 EGFR NAGPA SEMA4G	67 interacting genes: ADGRG3 AQP2 AQP6 ARL13B BCL2L13 BIK C5AR2 CALM1 CCRL2 CD79A CISD2 CLDN9 CREB3L1 CXCR2 CYBC1 DEGS1 EBP ERGIC3 FAM174A FAM209A FFAR2 GJA5 GJB4 GJB5 GLP1R GPR61 HHATL HTR2C JAGN1 LAPTM5 LMNA LY6G6C MFSD14B MILR1 MMD MMGT1 MRM3 MS4A3 NCAPH2 PLEKHO1 PTGES REEP4 RETREG3 RHBDL1 RHCG SERINC2 SHISAL1 SLC14A2 SLC19A3 SLC35C2 SLC35E3 SLC39A2 SLC41A3 SLCO3A1 SMO SSMEM1 STX1A SYNPR TIMMDC1 TM4SF19 TMEM101 TMEM237 TMEM248 TMEM45A TMEM45B TMEM51 YIF1A
Entrez ID		8560	401152
HPRD ID		13133	14223
Ensembl ID		ENSG00000143753	ENSG00000164096
Uniprot IDs		A0A024R3P1 O15121	Q8WVX3
PDB IDs
Enriched GO Terms of Interacting Partners?
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