AP3B1 and ATR

Number of citations of the paper that reports this interaction (PubMedID 10608806)
272

Data Source:
BioGRID (unspecified method)

		AP3B1	ATR
Description		adaptor related protein complex 3 subunit beta 1	ATR serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Synapse Axon Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus PML Body
	Molecular Function	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Cellular Protein Modification Process Protein Targeting To Lysosome Cellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Regulation Of Catalytic Activity Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development	DNA Damage Checkpoint Signaling Telomere Maintenance DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Multicellular Organism Development Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Peptidyl-serine Phosphorylation Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Pathways		Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions	Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Insulin resistance/response ( 21901158) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)	Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		19 interacting genes: AP3D1 AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 CXADR FCGR2B GKAP1 RNGTT SLC30A3 SSBP2 ZER1	50 interacting genes: AATF ABL1 AP1B1 AP3B1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB TP53 TREX1 UPF1 XPA XRCC5
Entrez ID		8546	545
HPRD ID		04551	08369
Ensembl ID		ENSG00000132842	ENSG00000175054
Uniprot IDs		A0A0S2Z5J4 O00203	Q13535
PDB IDs			5YZ0
Enriched GO Terms of Interacting Partners?
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