ATR and POLN

Number of citations of the paper that reports this interaction (PubMedID 21242293)
45

Data Source:
BioGRID (enzymatic study)

		ATR	POLN
Description		ATR serine/threonine kinase	DNA polymerase nu
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus PML Body	Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Serine Kinase Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Cyclin Binding
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Multicellular Organism Development Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Peptidyl-serine Phosphorylation Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly	Double-strand Break Repair Via Homologous Recombination DNA-dependent DNA Replication Double-strand Break Repair Translesion Synthesis Interstrand Cross-link Repair
Pathways		Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Alzheimer's disease ( 22159054) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Height ( 31562340)
Interacting Genes		50 interacting genes: AATF ABL1 AP1B1 AP3B1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB TP53 TREX1 UPF1 XPA XRCC5	2 interacting genes: ATR POLDIP2
Entrez ID		545	353497
HPRD ID		08369	17876
Ensembl ID		ENSG00000175054	ENSG00000130997
Uniprot IDs		Q13535	Q7Z5Q5
PDB IDs		5YZ0	4XVI 4XVK 4XVL 4XVM
Enriched GO Terms of Interacting Partners?
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