CAT and KEAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CAT	KEAP1
Description		catalase	kelch like ECH associated protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Peroxisome Targeting Sequence Binding Aminoacylase Activity Catalase Activity Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Response To Inactivity Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Response To Hyperoxia Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Phenylpropanoid Cellular Oxidant Detoxification	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Ub-specific processing proteases ROS sensing by NFE2L2 ROS sensing by NFE2L2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fomepizole Cannabidiol Medical Cannabis Nabiximols	Dimethyl fumarate
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		11 interacting genes: ABL1 ABL2 APP CD44 EHHADH KEAP1 OGT PRKRA PTPN11 SUMO4 TLR10	96 interacting genes: ADH5 AK4 AMER1 ANKS1A ARPC1B ASTN1 ATG5 BAD BNIP3L BPTF C2orf68 CARD10 CARM1 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DPP3 EAF1 EGFR ERBIN ERICH5 ETF1 FAM117B FBXL17 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL2 KLHL3 KPNA6 LAMC1 LAMTOR5 LONP1 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PANX1 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA RTN4R S1PR2 SDC1 SENP1 SLC5A5 SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC UBE2D1 USP15 VAC14 WDR83 WHRN ZNF121 ZNF177 ZNF266 ZSCAN32
Entrez ID		847	9817
HPRD ID		00282	12079
Ensembl ID		ENSG00000121691	ENSG00000079999
Uniprot IDs		A0A384P5Q0 P04040	A0A024R7C0 Q14145
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW	1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A
Enriched GO Terms of Interacting Partners?
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