KEAP1 and PPP1R13L

Number of citations of the paper that reports this interaction (PubMedID 29033244)
38

Data Source:
BioGRID (pull down, pull down)

		KEAP1	PPP1R13L
Description		kelch like ECH associated protein 1	protein phosphatase 1 regulatory subunit 13 like
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Nucleus Nucleoplasm Cytosol Cell Junction Intercellular Bridge
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Cadherin Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Apoptotic Process Post-embryonic Development Embryonic Camera-type Eye Development Multicellular Organism Growth Hair Cycle Positive Regulation Of Cell Differentiation Multicellular Organismal Homeostasis Cardiac Muscle Contraction
Pathways		Ub-specific processing proteases ROS sensing by NFE2L2 ROS sensing by NFE2L2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TP53 Activity through Association with Co-factors
Drugs		Dimethyl fumarate
Diseases
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Platelet count ( 32888494)
Interacting Genes		96 interacting genes: ADH5 AK4 AMER1 ANKS1A ARPC1B ASTN1 ATG5 BAD BNIP3L BPTF C2orf68 CARD10 CARM1 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DPP3 EAF1 EGFR ERBIN ERICH5 ETF1 FAM117B FBXL17 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL2 KLHL3 KPNA6 LAMC1 LAMTOR5 LONP1 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PANX1 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA RTN4R S1PR2 SDC1 SENP1 SLC5A5 SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC UBE2D1 USP15 VAC14 WDR83 WHRN ZNF121 ZNF177 ZNF266 ZSCAN32	7 interacting genes: KEAP1 PPP1CA RELA SHANK3 SP1 SRPK2 TP53
Entrez ID		9817	10848
HPRD ID		12079	09195
Ensembl ID		ENSG00000079999	ENSG00000104881
Uniprot IDs		A0A024R7C0 Q14145	A0A024R0Q5 Q8WUF5
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A	2VGE 6DCX 6HL6 6RZ3
Enriched GO Terms of Interacting Partners?
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