CAT and ABL2

Number of citations of the paper that reports this interaction (PubMedID 12777400)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)
HPRD (in vitro, in vivo)

		CAT	ABL2
Description		catalase	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol Actin Cytoskeleton
	Molecular Function	Peroxisome Targeting Sequence Binding Aminoacylase Activity Catalase Activity Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Response To Inactivity Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Response To Hyperoxia Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Phenylpropanoid Cellular Oxidant Detoxification	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling RAC1 GTPase cycle RAC3 GTPase cycle Negative regulation of FLT3
Drugs		Fomepizole Cannabidiol Medical Cannabis Nabiximols	ATP Dasatinib XL228 K-00546 Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269)	IgE grass sensitization ( 22036096)
Interacting Genes		11 interacting genes: ABL1 ABL2 APP CD44 EHHADH KEAP1 OGT PRKRA PTPN11 SUMO4 TLR10	35 interacting genes: ABI2 ABL1 AR BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PRRG4 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1
Entrez ID		847	27
HPRD ID		00282	01259
Ensembl ID		ENSG00000121691	ENSG00000143322
Uniprot IDs		A0A384P5Q0 P04040	P42684
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW	2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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