LCE3D and SDC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LCE3D	SDC3
Description		late cornified envelope 3D	syndecan 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Lumen Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Lysosomal Lumen Microspike Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Keratinization	Cell Migration
Pathways		Formation of the cornified envelope	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Psoriasis ( 25854761 20953190 23143594 19169255)	Loneliness ( 27629369) Systolic blood pressure ( 34074324)
Interacting Genes		55 interacting genes: ADAMTSL4 ALPP CCN3 CHIC2 CYSRT1 EFEMP1 EFEMP2 FBLN2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2C MDFI NBPF19 NOTCH2NLA PCSK5 RGS17 RGS20 SDC3 SPRY1 SPRY3 SRPK1 SRPK2 TENM4 TGFB1 TRIM42 TSPAN4 VWC2	32 interacting genes: AGR2 CASK CMTM7 COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KCNJ2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 LCE3D MDK PLN PTN SLC35A1 SMIM1 TMEM14C TMEM218 TUBA1A TUBB TUBB2A
Entrez ID		84648	9672
HPRD ID		17263	01719
Ensembl ID		ENSG00000163202	ENSG00000162512
Uniprot IDs		Q9BYE3	O75056
PDB IDs
Enriched GO Terms of Interacting Partners?
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