LCE3D and CCN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LCE3D	CCN3
Description		late cornified envelope 3D	cellular communication network factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Cytoplasm Gap Junction Axon Dendrite Extracellular Matrix Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Notch Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding
	Biological Process	Keratinization	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Death Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration
Pathways		Formation of the cornified envelope
Drugs			Insulin pork
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Psoriasis ( 25854761 20953190 23143594 19169255)
Interacting Genes		55 interacting genes: ADAMTSL4 ALPP CCN3 CHIC2 CYSRT1 EFEMP1 EFEMP2 FBLN2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2C MDFI NBPF19 NOTCH2NLA PCSK5 RGS17 RGS20 SDC3 SPRY1 SPRY3 SRPK1 SRPK2 TENM4 TGFB1 TRIM42 TSPAN4 VWC2	31 interacting genes: ADSL ANKRD11 APOL6 C11orf87 CCN2 CDKN1A COL8A1 DLL1 FAM90A1 FBLN1 FN1 FRS3 FXR1 FXR2 GJA1 HOXA1 IGF1 IGF2 INS ITGAV KRTAP5-6 LCE1A LCE3D NID2 NOTCH1 POLR2L POU4F2 RECK S100A4 TNIP3 ZNF330
Entrez ID		84648	4856
HPRD ID		17263	01291
Ensembl ID		ENSG00000163202	ENSG00000136999
Uniprot IDs		Q9BYE3	A0A024R9J4 P48745
PDB IDs
Enriched GO Terms of Interacting Partners?
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