GPR61 and KLRC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GPR61	KLRC1
Description		G protein-coupled receptor 61	killer cell lectin like receptor C1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Integral Component Of Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Arrestin Family Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of CAMP-mediated Signaling	Negative Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Chronotype ( 30696823) Hepcidin/ferritin ratio ( 27846281) Morning person ( 30696823) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Stearic acid (18:0) levels ( 23362303) Waist circumference ( 25673412)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Blood protein levels ( 28240269) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		20 interacting genes: APP ARL6IP6 ATP6V0B C4orf3 CLDND1 CTXN3 EMP3 FCER1G GJA8 GJB6 KLRC1 PLP1 PMP22 SCN3B SLC12A7 SLC13A4 STRIT1 TMEM147 TMEM218 TRARG1	46 interacting genes: ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC SUZ12 TMEM182 TMEM262 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1
Entrez ID		83873	3821
HPRD ID		06077	01192
Ensembl ID		ENSG00000156097	ENSG00000134545
Uniprot IDs		G4XH66 Q9BZJ8	P26715
PDB IDs			2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?
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