KLRC1 and GJB4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KLRC1	GJB4
Description		killer cell lectin like receptor C1	gap junction protein beta 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Nucleoplasm Nucleolus Integral Component Of Plasma Membrane Connexin Complex Cell Junction
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity	Cell-cell Signaling Sensory Perception Of Smell Olfactory Behavior Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Gap junction assembly
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Blood protein levels ( 28240269) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)	Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		46 interacting genes: ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC SUZ12 TMEM182 TMEM262 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1	9 interacting genes: C4orf3 COMT KLRC1 LHFPL5 TM4SF4 TMBIM6 TMEM11 TMEM218 TMEM86A
Entrez ID		3821	127534
HPRD ID		01192	05666
Ensembl ID		ENSG00000134545	ENSG00000189433
Uniprot IDs		P26715	A0A654IBS8 Q9NTQ9
PDB IDs		2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?
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