APH1B and NCSTN

Number of citations of the paper that reports this interaction (PubMedID 12857757)
74

Data Source:
HPRD (in vitro, in vivo)

		APH1B	NCSTN
Description		aph-1 homolog B, gamma-secretase subunit	nicastrin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Endosome Membrane Integral Component Of Membrane Transport Vesicle Gamma-secretase Complex	Mitochondrion Lysosomal Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Azurophil Granule Membrane Sarcolemma Melanosome Extracellular Exosome Gamma-secretase Complex Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	Protein Binding Protein-macromolecule Adaptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving ATPase Binding Growth Factor Receptor Binding
	Biological Process	Notch Signaling Pathway Notch Receptor Processing Locomotory Behavior Positive Regulation Of Endopeptidase Activity Protein Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Learning Or Memory Positive Regulation Of Endopeptidase Activity Protein Processing Cerebellum Development Central Nervous System Myelination Adult Behavior Amyloid-beta Formation T Cell Proliferation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Catalytic Activity Epithelial Cell Proliferation Neuron Apoptotic Process Cellular Response To Calcium Ion Regulation Of Long-term Synaptic Potentiation Short-term Synaptic Potentiation
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation	Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		8 interacting genes: FXYD6-FXYD2 NAB2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1	12 interacting genes: ABL1 APH1A APH1B APP BACE1 MAPK9 PSEN1 PSEN2 PSENEN PTEN SPP1 TMED10
Entrez ID		83464	23385
HPRD ID		06361	05584
Ensembl ID		ENSG00000138613	ENSG00000162736
Uniprot IDs		Q8WW43	B4DR82 Q92542
PDB IDs			2N7Q 2N7R 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X
Enriched GO Terms of Interacting Partners?
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