APH1B and FXYD6-FXYD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APH1B	FXYD6-FXYD2
Description		aph-1 homolog B, gamma-secretase subunit	FXYD6-FXYD2 readthrough
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Endosome Membrane Integral Component Of Membrane Transport Vesicle Gamma-secretase Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Notch Signaling Pathway Notch Receptor Processing Locomotory Behavior Positive Regulation Of Endopeptidase Activity Protein Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		8 interacting genes: FXYD6-FXYD2 NAB2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1	33 interacting genes: APH1B APOL3 AQP6 AVPR2 BEST1 BNIP3 CERS4 CLDN5 FAM210B GPR152 GPR37L1 GPRC5D MTIF3 PGRMC2 RNF170 SLC10A1 SLC10A6 SLC16A13 SLC19A3 SLC2A13 SLC34A2 SLC35C2 SLC7A8 SPCS1 TLCD4 TMEM14B TMEM167B TMEM205 TMEM41A TMPPE TMX2 TRHR UNC93A
Entrez ID		83464	100533181
HPRD ID		06361
Ensembl ID		ENSG00000138613	ENSG00000255245
Uniprot IDs		Q8WW43	A0A087WZ82 A0A0A6YYL5
PDB IDs
Enriched GO Terms of Interacting Partners?
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