LRRK1 and CDC42EP3

Number of citations of the paper that reports this interaction (PubMedID 29513927)
16

Data Source:
BioGRID (pull down)

		LRRK1	CDC42EP3
Description		leucine rich repeat kinase 1	CDC42 effector protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Actin Cytoskeleton
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Cytoskeletal Regulatory Protein Binding
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly
Pathways			MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS		Central corneal thickness ( 32528159 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Facial attractiveness (male raters) ( 30946739) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 20881960 23563607 31562340) Night sleep phenotypes ( 27126917) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Waist circumference adjusted for body mass index ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SELENOS SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP TM2D3 VGLL4	12 interacting genes: CDC42 COPE DAPK1 LRRK1 LRRK2 MFHAS1 RHOQ SEPTIN6 SEPTIN7 SNCA SRPK1 UMPS
Entrez ID		79705	10602
HPRD ID		14319	09364
Ensembl ID		ENSG00000154237	ENSG00000163171
Uniprot IDs		Q38SD2	Q9UKI2
PDB IDs
Enriched GO Terms of Interacting Partners?
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