CDC42EP3 and UMPS

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC42EP3	UMPS
Description		CDC42 effector protein 3	uridine monophosphate synthetase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Actin Cytoskeleton	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Cytoskeletal Regulatory Protein Binding	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity
	Biological Process	Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly	'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Nucleoside Metabolic Process Pyrimidine Nucleobase Biosynthetic Process 'de Novo' UMP Biosynthetic Process Cellular Response To Xenobiotic Stimulus
Pathways		MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle	Pyrimidine biosynthesis
Drugs			6-hydroxyuridine-5'-phosphate
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Facial attractiveness (male raters) ( 30946739) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 20881960 23563607 31562340) Night sleep phenotypes ( 27126917) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Waist circumference adjusted for body mass index ( 34021172) Youthful appearance (self-reported) ( 32339537)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Plateletcrit ( 32888494) Serum metabolite levels ( 33031748)
Interacting Genes		12 interacting genes: CDC42 COPE DAPK1 LRRK1 LRRK2 MFHAS1 RHOQ SEPTIN6 SEPTIN7 SNCA SRPK1 UMPS	16 interacting genes: A2M CALU CASP8 CDC42EP3 DLST NOS3 OGT PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 SUMO2 ZNF227
Entrez ID		10602	7372
HPRD ID		09364	02022
Ensembl ID		ENSG00000163171	ENSG00000114491
Uniprot IDs		Q9UKI2	A8K5J1 P11172
PDB IDs			2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
Enriched GO Terms of Interacting Partners?
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