ALG8 and NARS2

		ALG8	NARS2
Description		ALG8 alpha-1,3-glucosyltransferase	asparaginyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Nucleic Acid Binding Asparagine-tRNA Ligase Activity ATP Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation	Asparaginyl-tRNA Aminoacylation
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)	Mitochondrial tRNA aminoacylation
Drugs			Asparagine
Diseases
GWAS		Depression in smokers ( 30219690) Tourette syndrome ( 30818990)	Alzheimer's disease (survival time) ( 25649651) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Estimated glomerular filtration rate ( 31451708) High light scatter reticulocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990) Verbal declarative memory ( 25648963)
Interacting Genes		16 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 IQGAP2 LMNA MFSD6 NAE1 NARS2 RPS6KA5 RSF1 SAR1A TMEM126B	5 interacting genes: ALG8 FAM181B INTS4 KCTD14 TMEM126B
Entrez ID		79053	79731
HPRD ID		10480	08026
Ensembl ID		ENSG00000159063	ENSG00000137513
Uniprot IDs		A0A024R5K5 Q9BVK2	B3KPX5 Q96I59 Q9H5H1
PDB IDs
Enriched GO Terms of Interacting Partners?
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