ALG8 and CLRN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALG8	CLRN1
Description		ALG8 alpha-1,3-glucosyltransferase	clarin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Plasma Membrane Microvillus Microtubule Cytoskeleton Integral Component Of Membrane Lamellipodium Trans-Golgi Network Transport Vesicle Stereocilium Basal Part Of Cell
	Molecular Function	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Protein Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation	Actin Filament Organization Visual Perception Sensory Perception Of Sound Positive Regulation Of Lamellipodium Assembly Photoreceptor Cell Maintenance Cell Motility Response To Stimulus Sensory Perception Of Light Stimulus Equilibrioception Auditory Receptor Cell Stereocilium Organization
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Tourette syndrome ( 30818990)	Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Chronotype ( 30696823) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600)
Interacting Genes		16 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 IQGAP2 LMNA MFSD6 NAE1 NARS2 RPS6KA5 RSF1 SAR1A TMEM126B	29 interacting genes: ALG8 BRICD5 C2CD2L CANT1 CCL4L2 CLDN19 CTXN3 DRAM1 FAM24B FUT9 ITGAM MFSD5 MGST3 MLF1 NRM SEC22B SLC34A3 TMEM140 TMEM147 TMEM222 TMEM239 TMEM31 TMEM50B TMEM86B TMIE TMPPE TMPRSS4 UNC50 ZDHHC15
Entrez ID		79053	7401
HPRD ID		10480	05905
Ensembl ID		ENSG00000159063	ENSG00000163646
Uniprot IDs		A0A024R5K5 Q9BVK2	P58418
PDB IDs
Enriched GO Terms of Interacting Partners?
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