ALG8 and RSF1

		ALG8	RSF1
Description		ALG8 alpha-1,3-glucosyltransferase	remodeling and spacing factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Nucleoplasm RSF Complex
	Molecular Function	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Transcription Coregulator Activity Protein Binding ATP Hydrolysis Activity Histone Binding Metal Ion Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation	Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription, Initiation Nucleosome Positioning Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Tourette syndrome ( 30818990)	Left-handedness ( 32989287) Tourette syndrome ( 30818990)
Interacting Genes		16 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 IQGAP2 LMNA MFSD6 NAE1 NARS2 RPS6KA5 RSF1 SAR1A TMEM126B	6 interacting genes: ALG8 CSNK2A1 HMGB1 NFKB1 SMARCA5 TENM4
Entrez ID		79053	51773
HPRD ID		10480	10537
Ensembl ID		ENSG00000159063	ENSG00000048649
Uniprot IDs		A0A024R5K5 Q9BVK2	Q05DG0 Q96T23
PDB IDs
Enriched GO Terms of Interacting Partners?
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