RAB7A and RPN1

Number of citations of the paper that reports this interaction (PubMedID 34079125)
7

Data Source:
BioGRID (proximity labelling technology)

		RAB7A	RPN1
Description		RAB7A, member RAS oncogene family	ribophorin I
Image
GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Cellular Protein Modification Process Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil counts ( 29403010 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Serum metabolite levels ( 33031748) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 21738480) White blood cell count (basophil) ( 29403010)
Interacting Genes		35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2	17 interacting genes: ADRM1 DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 RAB7A RAD23A RBBP4 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		7879	6184
HPRD ID		03805	01598
Ensembl ID		ENSG00000075785	ENSG00000163902
Uniprot IDs		A0A158RFU6 P51149	P04843
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW	6S7O 6S7T
Enriched GO Terms of Interacting Partners?
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