RPN1 and RAB7A

Number of citations of the paper that reports this interaction (PubMedID 34079125)
7

Data Source:
BioGRID (proximity labelling technology)

		RPN1	RAB7A
Description		ribophorin I	RAB7A, member RAS oncogene family
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Cellular Protein Modification Process Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil counts ( 29403010 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Serum metabolite levels ( 33031748) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 21738480) White blood cell count (basophil) ( 29403010)	Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		17 interacting genes: ADRM1 DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 RAB7A RAD23A RBBP4 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2	35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2
Entrez ID		6184	7879
HPRD ID		01598	03805
Ensembl ID		ENSG00000163902	ENSG00000075785
Uniprot IDs		P04843	A0A158RFU6 P51149
PDB IDs		6S7O 6S7T	1T91 1YHN 3LAW 6IYB 6WCW
Enriched GO Terms of Interacting Partners?
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