ZNF177 and SNAP25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZNF177	SNAP25
Description		zinc finger protein 177	synaptosome associated protein 25
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Blood Microparticle	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Membrane Growth Cone SNARE Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Neurotransmitter Uptake Exocytosis Vesicle Fusion Chemical Synaptic Transmission Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Potassium Ion Transmembrane Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Neurotransmitter Receptor Internalization
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs			Botulinum toxin type A
Diseases
GWAS			Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		22 interacting genes: ARHGAP21 BOLA2 BOLA2B CIB3 CSNK2A1 CT55 EXOC8 KEAP1 LMO1 MID2 MLH1 PMVK PRKAB2 PRKAR1B PSMB1 RHOU SLC37A3 SNAP25 SNAPC5 TRAF4 TYK2 ZGPAT	39 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		7730	6616
HPRD ID		03175	02637
Ensembl ID		ENSG00000188629	ENSG00000132639
Uniprot IDs		Q13360	P60880
PDB IDs			1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH
Enriched GO Terms of Interacting Partners?
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