SNAP25 and RIMS1

Number of citations of the paper that reports this interaction (PubMedID 11438521)
12

Data Source:
HPRD (in vitro)

		SNAP25	RIMS1
Description		synaptosome associated protein 25	regulating synaptic membrane exocytosis 1
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Membrane Growth Cone SNARE Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Postsynapse Glutamatergic Synapse	Cytosol Plasma Membrane Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone
	Molecular Function	Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding	RNA Binding Protein Binding GTPase Regulator Activity Small GTPase Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Neurotransmitter Uptake Exocytosis Vesicle Fusion Chemical Synaptic Transmission Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Potassium Ion Transmembrane Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Neurotransmitter Receptor Internalization	Intracellular Protein Transport Visual Perception Positive Regulation Of Gene Expression Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Cell Differentiation Regulation Of Membrane Potential Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Positive Regulation Of Synaptic Transmission Response To Stimulus Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs		Botulinum toxin type A
Diseases
GWAS		Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 29483656 30285260) Squamous cell lung carcinoma ( 28604730) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32203549)
Interacting Genes		39 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177	17 interacting genes: CACNA1B CACNA1C CAMK2A COL9A1 ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B VAV1 YWHAH
Entrez ID		6616	22999
HPRD ID		02637	09435
Ensembl ID		ENSG00000132639	ENSG00000079841
Uniprot IDs		P60880	B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5
PDB IDs		1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH	2CSS
Enriched GO Terms of Interacting Partners?
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