ZNF177 and PMVK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZNF177	PMVK
Description		zinc finger protein 177	phosphomevalonate kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Blood Microparticle	Peroxisome Cytosol Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Phosphomevalonate Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Response To Cholesterol
Pathways			Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs
Diseases
GWAS			Atrial fibrillation ( 29892015 22544366) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Inflammatory bowel disease ( 27569725) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732)
Interacting Genes		22 interacting genes: ARHGAP21 BOLA2 BOLA2B CIB3 CSNK2A1 CT55 EXOC8 KEAP1 LMO1 MID2 MLH1 PMVK PRKAB2 PRKAR1B PSMB1 RHOU SLC37A3 SNAP25 SNAPC5 TRAF4 TYK2 ZGPAT	4 interacting genes: DDIT4L MCPH1 ZNF177 ZNF559-ZNF177
Entrez ID		7730	10654
HPRD ID		03175	07404
Ensembl ID		ENSG00000188629	ENSG00000163344
Uniprot IDs		Q13360	Q15126 Q6FGV9
PDB IDs			3CH4
Enriched GO Terms of Interacting Partners?
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