PMVK and ZNF559-ZNF177

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PMVK	ZNF559-ZNF177
Description		phosphomevalonate kinase	ZNF559-ZNF177 readthrough
Image			No pdb structure
GO Annotations	Cellular Component	Peroxisome Cytosol Membrane Extracellular Exosome	Nucleus Blood Microparticle
	Molecular Function	Phosphomevalonate Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Response To Cholesterol	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 22544366) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Inflammatory bowel disease ( 27569725) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: DDIT4L MCPH1 ZNF177 ZNF559-ZNF177	17 interacting genes: BOLA2 BOLA2B CIB3 CSNK2A1 CT55 EXOC8 LMO1 MID2 MLH1 PMVK PRKAB2 PRKAR1B PSMB1 SNAP25 SNAPC5 TRAF4 ZGPAT
Entrez ID		10654	100529215
HPRD ID		07404
Ensembl ID		ENSG00000163344	ENSG00000270011
Uniprot IDs		Q15126 Q6FGV9	Q13360
PDB IDs		3CH4
Enriched GO Terms of Interacting Partners?
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