CA1 and HSD17B7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CA1	HSD17B7
Description		carbonic anhydrase 1	hydroxysteroid 17-beta dehydrogenase 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Arylesterase Activity Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity	3-keto Sterol Reductase Activity Estradiol 17-beta-dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	One-carbon Metabolic Process	Cholesterol Biosynthetic Process Estrogen Biosynthetic Process Androgen Metabolic Process
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Cholesterol biosynthesis
Drugs		Methyclothiazide Topiramate Chlorthalidone Ethoxzolamide Amlodipine Methocarbamol Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Trichlormethiazide Ethinamate Diazoxide Diclofenamide Brinzolamide Quinethazone N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Ellagic acid Sodium carbonate Sodium sulfate	NADH
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Blood trace element (Zn levels) ( 23720494) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Zinc levels ( 26025379)	Dupuytren's disease ( 28886342)
Interacting Genes		3 interacting genes: HSD17B7 MAPK6 TFCP2	7 interacting genes: BRSK1 CA1 DTYMK GORAB GPAT4 PBRM1 VKORC1
Entrez ID		759	51478
HPRD ID		00265	05996
Ensembl ID		ENSG00000133742	ENSG00000132196
Uniprot IDs		P00915 V9HWE3	A0A024R913 P56937 Q9H9C0
PDB IDs		1AZM 1BZM 1CRM 1CZM 1HCB 1HUG 1HUH 1J9W 1JV0 2CAB 2FOY 2FW4 2IT4 2NMX 2NN1 2NN7 3LXE 3W6H 3W6I 4WR7 4WUP 4WUQ 5E2M 5GMM 6EVR 6EX1 6F3B 6FAF 6FAG 6G3V 6HWZ 6I0J 6I0L 6SWM 6XZE 6XZO 6XZS 6XZX 6XZY 6Y00
Enriched GO Terms of Interacting Partners?
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