CA1 and TFCP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		CA1	TFCP2
Description		carbonic anhydrase 1	transcription factor CP2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	Arylesterase Activity Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	One-carbon Metabolic Process	Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Methyclothiazide Topiramate Chlorthalidone Ethoxzolamide Amlodipine Methocarbamol Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Trichlormethiazide Ethinamate Diazoxide Diclofenamide Brinzolamide Quinethazone N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Ellagic acid Sodium carbonate Sodium sulfate
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Blood trace element (Zn levels) ( 23720494) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Zinc levels ( 26025379)
Interacting Genes		3 interacting genes: HSD17B7 MAPK6 TFCP2	74 interacting genes: ACAA1 ADPRH APBB1 ASAP3 BAG6 C19orf73 CA1 CAPN3 CASP8 CBX8 CDC73 COIL DNAJC5B DPH1 E2F8 EAF1 EIF5B EPHA10 FAM120C FANCL FARS2 FBXL18 FXR2 GPANK1 HAPLN2 HDAC1 HDAC2 IRAK1BP1 LDB3 LSM1 MAPK1 MAPK14 MAPK8 MOB3C MORF4L1 MRPL11 MRPL40 MVP NABP1 NEDD9 NFE4 NHSL2 NOM1 NPEPL1 PHF1 PHF21B PIMREG PITPNM1 PLCB1 POLL POLR3GL PPIG PPP1R1B PPP3R2 PSMD5 RBMS1 RNF2 RXRB SDCBP SHTN1 SIN3A STMN2 SUMO1 TCEA2 TDRD1 TLK1 TRAPPC12 TSPAN12 UBE2I UBP1 YJU2 YY1 ZCCHC10 ZCCHC12
Entrez ID		759	7024
HPRD ID		00265	01790
Ensembl ID		ENSG00000133742	ENSG00000135457
Uniprot IDs		P00915 V9HWE3	A0A024R120 Q12800
PDB IDs		1AZM 1BZM 1CRM 1CZM 1HCB 1HUG 1HUH 1J9W 1JV0 2CAB 2FOY 2FW4 2IT4 2NMX 2NN1 2NN7 3LXE 3W6H 3W6I 4WR7 4WUP 4WUQ 5E2M 5GMM 6EVR 6EX1 6F3B 6FAF 6FAG 6G3V 6HWZ 6I0J 6I0L 6SWM 6XZE 6XZO 6XZS 6XZX 6XZY 6Y00
Enriched GO Terms of Interacting Partners?
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