UTY and PRDX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		UTY	PRDX2
Description		ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	peroxiredoxin 2
Image
GO Annotations	Cellular Component	Nucleoplasm MLL3/4 Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3-tri/di-methyl-lysine-27 Demethylase Activity	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity
	Biological Process	Heart Development Regulation Of Gene Expression Histone H3-K27 Demethylation	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		HDMs demethylate histones	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Autism ( 32996047)	Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: PRDX2 TLE1 TLE2	25 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 TYK2 UTY YWHAZ
Entrez ID		7404	7001
HPRD ID		02451	02763
Ensembl ID		ENSG00000183878	ENSG00000167815
Uniprot IDs		A0A087X0Y2 A0A087X248 A0A087X2I9 A0A096LPD8 E1NZ93 E1U198 E1U1M3 E1U1M9 F4MH27 F4MH29 F4MH30 F4MH31 F4MH32 F4MH35 F4MH36 F4MH40 F4MH46 F4MH47 F4MH50 F4MH51 F4MH58 F4MH60 F4MH62 F4MH91 F4MH92 F5GWV3 F5H3N7 F5H8B4 O14607	P32119 V9HW12
PDB IDs		3ZLI 3ZPO 4UF0 5A1L 5FXV 5FXW 5FXX 5FXZ 5FY0 5FY1 5FY7 5FYM	1QMV 5B8A 5B8B 5IJT
Enriched GO Terms of Interacting Partners?
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