HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
PRDX2 and BAD
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
PRDX2
BAD
Description
peroxiredoxin 2
BCL2 associated agonist of cell death
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Exosome
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Molecular Function
Protein Binding
Thioredoxin Peroxidase Activity
Antioxidant Activity
Protein Binding
Phospholipid Binding
Lipid Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Kinase Binding
Protein Phosphatase Binding
Protein Phosphatase 2B Binding
Protein Kinase B Binding
14-3-3 Protein Binding
Biological Process
Defense Response To Tumor Cell
Respiratory Burst Involved In Inflammatory Response
Response To Oxidative Stress
Regulation Of Hydrogen Peroxide Metabolic Process
Removal Of Superoxide Radicals
Positive Regulation Of Blood Coagulation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Lipopolysaccharide
Cellular Response To Stress
Cellular Response To Oxidative Stress
T Cell Proliferation
Hydrogen Peroxide Catabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Leukocyte Activation
Cell Redox Homeostasis
Negative Regulation Of T Cell Differentiation
Thymus Development
Homeostasis Of Number Of Cells
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Release Of Cytochrome C From Mitochondria
Glucose Catabolic Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Spermatogenesis
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Response To Glucose
Positive Regulation Of Autophagy
Positive Regulation Of Mitochondrial Membrane Potential
Cytokine-mediated Signaling Pathway
Cerebral Cortex Development
Positive Regulation Of Insulin Secretion
Response To Estradiol
Response To Progesterone
Positive Regulation Of Glucokinase Activity
Response To Testosterone
Response To Oleic Acid
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Hydrogen Peroxide
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Type B Pancreatic Cell Proliferation
Response To Ethanol
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Proteolysis
ADP Metabolic Process
ATP Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Pore Complex Assembly
Positive Regulation Of Epithelial Cell Proliferation
Response To Glucocorticoid
Response To Calcium Ion
Cellular Response To Chromate
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Lipid
Cellular Response To Hypoxia
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Neuron Death
Response To Benzene
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Granulosa Cell Apoptotic Process
Positive Regulation Of Type B Pancreatic Cell Development
Pathways
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Activation of BAD and translocation to mitochondria
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
Drugs
3-sulfino-L-alanine
N-Carbamoyl-Alanine
Copper
Navitoclax
Diseases
GWAS
Platelet distribution width (
32888494
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Platelet count (
22423221
)
Sarcoidosis (
22837380
)
Vitiligo (
27723757
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
25 interacting genes:
A2M
APOE
APP
BAD
CA4
CD320
CDC37
COPS5
ECSIT
EXOC6
IFIT5
MAST1
NLGN3
PDGFRB
PPP2R1A
PPP2R1B
PRDX4
PSEN1
RNF32
SAT1
SUMO4
TXNDC5
TYK2
UTY
YWHAZ
46 interacting genes:
ACTN2
AKT1
ARAF
BBS1
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BRAF
CDKN1A
CREB3L3
EWSR1
HRK
KEAP1
KRT31
MAP2K5
MAPK8
MCL1
PAK1
PAK5
PIM1
PIM2
PIM3
PPP1CA
PPP3CA
PRDX2
PRKACA
PRKCI
RAF1
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA5
S100A10
SFN
SNCA
STEAP3
SUMO2
WASF1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
7001
572
HPRD ID
02763
04409
Ensembl ID
ENSG00000167815
ENSG00000002330
Uniprot IDs
P32119
V9HW12
A0A024R562
Q92934
PDB IDs
1QMV
5B8A
5B8B
5IJT
1G5J
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?