UTY and TLE1

Number of citations of the paper that reports this interaction (PubMedID 9854018)
21

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		UTY	TLE1
Description		ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	TLE family member 1, transcriptional corepressor
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GO Annotations	Cellular Component	Nucleoplasm MLL3/4 Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3-tri/di-methyl-lysine-27 Demethylase Activity	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Heart Development Regulation Of Gene Expression Histone H3-K27 Demethylation	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis
Pathways		HDMs demethylate histones	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Autism ( 32996047)	Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 32499647 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Interacting Genes		3 interacting genes: PRDX2 TLE1 TLE2	88 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 DNAH5 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GKAP1 GOLM1 GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 KIF27 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64
Entrez ID		7404	7088
HPRD ID		02451	02557
Ensembl ID		ENSG00000183878	ENSG00000196781
Uniprot IDs		A0A087X0Y2 A0A087X248 A0A087X2I9 A0A096LPD8 E1NZ93 E1U198 E1U1M3 E1U1M9 F4MH27 F4MH29 F4MH30 F4MH31 F4MH32 F4MH35 F4MH36 F4MH40 F4MH46 F4MH47 F4MH50 F4MH51 F4MH58 F4MH60 F4MH62 F4MH91 F4MH92 F5GWV3 F5H3N7 F5H8B4 O14607	B4DEF9 Q04724 Q59EF7
PDB IDs		3ZLI 3ZPO 4UF0 5A1L 5FXV 5FXW 5FXX 5FXZ 5FY0 5FY1 5FY7 5FYM	1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?
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