TYK2 and MTTP

		TYK2	MTTP
Description		tyrosine kinase 2	microsomal triglyceride transfer protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Apparatus Basolateral Plasma Membrane Brush Border Membrane Microvillus Membrane Vesicle Receptor Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Apolipoprotein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Phospholipid Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Triglyceride Transfer Activity Ceramide 1-phosphate Transfer Activity Phosphatidylethanolamine Transfer Activity
	Biological Process	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Type I Interferon Signaling Pathway	Protein Lipidation Lipid Metabolic Process Triglyceride Metabolic Process Circadian Rhythm Protein Secretion Phospholipid Transport Sterol Transport Triglyceride Transport Low-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Lipoprotein Transport Response To Calcium Ion Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	VLDL assembly Chylomicron assembly
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Tofacitinib Fostamatinib	Hesperetin Implitapide SLx-4090 Lomitapide
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 25751624 32005708 19966805) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Celiac disease ( 23936387) HDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465) Regular attendance at a pub or social club ( 29970889) Triglyceride levels ( 32203549)
Interacting Genes		52 interacting genes: APOBEC3F ARMC6 CBL COPS5 CRKL CYSRT1 DHX9 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN MTTP PDGFRB PIK3R1 PLAUR PRDM5 PRDX2 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RAB11B RACK1 SOCS1 STAM2 STAT1 STAT2 SULT1A1 TK1 TP53BP2 TRAF4 VAV1 XRCC5 ZNF177	3 interacting genes: APOB HSP90B1 TYK2
Entrez ID		7297	4547
HPRD ID		01490	01144
Ensembl ID		ENSG00000105397	ENSG00000138823
Uniprot IDs		A0A024R7E4 P29597	B7Z7X3 E9PBP6 P55157
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY 6X8F 6X8G
Enriched GO Terms of Interacting Partners?
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