TYK2 and APOBEC3F

		TYK2	APOBEC3F
Description		tyrosine kinase 2	apolipoprotein B mRNA editing enzyme catalytic subunit 3F
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome	P-body Nucleus Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex Ribonucleoprotein Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Deoxycytidine Deaminase Activity
	Biological Process	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Type I Interferon Signaling Pathway	Positive Regulation Of Defense Response To Virus By Host Cytidine Deamination Negative Regulation Of Transposition Base Conversion Or Substitution Editing Cytidine To Uridine Editing Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Viral Process Defense Response To Virus DNA Cytosine Deamination DNA Demethylation
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Tofacitinib Fostamatinib
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 25751624 32005708 19966805) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)
Interacting Genes		52 interacting genes: APOBEC3F ARMC6 CBL COPS5 CRKL CYSRT1 DHX9 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN MTTP PDGFRB PIK3R1 PLAUR PRDM5 PRDX2 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RAB11B RACK1 SOCS1 STAM2 STAT1 STAT2 SULT1A1 TK1 TP53BP2 TRAF4 VAV1 XRCC5 ZNF177	6 interacting genes: ACD APOBEC3G ARIH2 RNF7 TINF2 TYK2
Entrez ID		7297	200316
HPRD ID		01490	16415
Ensembl ID		ENSG00000105397	ENSG00000128394
Uniprot IDs		A0A024R7E4 P29597	Q8IUX4
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY 6X8F 6X8G	3WUS 4IOU 4J4J 5HX4 5HX5 5W2M 6NIL
Enriched GO Terms of Interacting Partners?
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