MTTP and APOB

Number of citations of the paper that reports this interaction (PubMedID 9915855)
13

Data Source:
HPRD (two hybrid, in vivo)

		MTTP	APOB
Description		microsomal triglyceride transfer protein	apolipoprotein B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Apparatus Basolateral Plasma Membrane Brush Border Membrane Microvillus Membrane Vesicle Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Vesicle Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen
	Molecular Function	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Apolipoprotein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Phospholipid Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Triglyceride Transfer Activity Ceramide 1-phosphate Transfer Activity Phosphatidylethanolamine Transfer Activity	Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Protein Lipidation Lipid Metabolic Process Triglyceride Metabolic Process Circadian Rhythm Protein Secretion Phospholipid Transport Sterol Transport Triglyceride Transport Low-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Lipoprotein Transport Response To Calcium Ion Intermembrane Lipid Transfer Ceramide 1-phosphate Transport	In Utero Embryonic Development Triglyceride Mobilization Spermatogenesis Nervous System Development Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Response To Estradiol Response To Lipopolysaccharide Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus Intermembrane Lipid Transfer
Pathways		VLDL assembly Chylomicron assembly	Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		Hesperetin Implitapide SLx-4090 Lomitapide	Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Celiac disease ( 23936387) HDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465) Regular attendance at a pub or social club ( 29970889) Triglyceride levels ( 32203549)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549 33730874) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Blood protein levels ( 29875488 28240269) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 20864672 19060911 30275531 25961943 20686565) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 24097068 24507774 21059979 18193043 18193044 20864672 19060906 19060910 19060911 30275531 21347282 25961943 26780889 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 26690388 31087446 32759990 17463246 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 33339817 31969989) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) NHDL cholesterol levels ( 32902719) Oxidized LDL cholesterol levels ( 31150472) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Response to statins (LDL cholesterol change) ( 31969989) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 28334899 32902719 26690388 31087446 33339817 30275531) Triglyceride levels ( 32203549 32154731 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 20864672 26160806 19060906 19060911 25961943 20686565)
Interacting Genes		3 interacting genes: APOB HSP90B1 TYK2	24 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2
Entrez ID		4547	338
HPRD ID		01144	00133
Ensembl ID		ENSG00000138823	ENSG00000084674
Uniprot IDs		B7Z7X3 E9PBP6 P55157	P04114 Q59HB3 Q7Z7Q0
PDB IDs
Enriched GO Terms of Interacting Partners?
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