ACD and RECQL4

Number of citations of the paper that reports this interaction (PubMedID 21044950)
51

Data Source:
BioGRID (two hybrid)

		ACD	RECQL4
Description		ACD shelterin complex subunit and telomerase recruitment factor	RecQ like helicase 4
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Membrane
	Molecular Function	Protein Binding Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding	Bubble DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity Oxidized Purine DNA Binding ATP-dependent DNA/DNA Annealing Activity 3'-5' DNA Helicase Activity Telomeric D-loop Binding
	Biological Process	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Segmentation Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Multicellular Organism Development DNA Duplex Unwinding Telomeric D-loop Disassembly
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		65 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA ESRP2 FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790	8 interacting genes: ACD EP300 FOXH1 MCM10 POT1 PRSS23 TERF1 TERF2IP
Entrez ID		65057	9401
HPRD ID		12417	04805
Ensembl ID		ENSG00000102977	ENSG00000160957
Uniprot IDs		A0A590TQL1 Q96AP0	O94761
PDB IDs		2I46 5H65 5I2X 5I2Y 5UN7 5XYF	2KMU 5LST
Enriched GO Terms of Interacting Partners?
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