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ACD and FBXW7
Number of citations of the paper that reports this interaction (PubMedID
33086033
)
3
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down, two hybrid)
ACD
FBXW7
Description
ACD shelterin complex subunit and telomerase recruitment factor
F-box and WD repeat domain containing 7
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleoplasm
Telomerase Holoenzyme Complex
Nuclear Body
Shelterin Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
SCF Ubiquitin Ligase Complex
Perinuclear Region Of Cytoplasm
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Protein Binding
Cyclin Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin Binding
Phosphothreonine Residue Binding
Ubiquitin-protein Transferase Activator Activity
Biological Process
Telomere Maintenance
Skeletal System Development
Urogenital System Development
Intracellular Protein Transport
Telomere Maintenance Via Telomerase
Telomere Capping
Embryonic Limb Morphogenesis
Protection From Non-homologous End Joining At Telomere
Telomere Assembly
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Segmentation
Positive Regulation Of Telomerase Activity
Positive Regulation Of Single-stranded Telomeric DNA Binding
Protein Localization To Chromosome, Telomeric Region
Establishment Of Protein Localization To Telomere
Vasculogenesis
Vasculature Development
Sister Chromatid Cohesion
Notch Signaling Pathway
Negative Regulation Of Gene Expression
Negative Regulation Of Triglyceride Biosynthetic Process
Regulation Of Lipid Storage
Ubiquitin Recycling
Protein Ubiquitination
Lung Development
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of Protein Localization
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Rhythmic Process
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Lipid Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of SREBP Signaling Pathway
Negative Regulation Of Osteoclast Development
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Hemoglobin levels (
32327693
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Interacting Genes
65 interacting genes:
ACTB
ADPRH
AFAP1L2
AIPL1
ANKMY2
ANXA8L1
APOBEC3F
BAG3
CKB
CTTN
DBN1
DBNL
DCX
DPYSL3
EIF3G
EIF4B
ENO2
ENSA
ESRP2
FAM131B
FBXW7
FKBP6
GAPDH
HSP90AB1
IPO5
IVL
LASP1
LDHA
LGALSL
LLGL1
LRRC25
NCDN
NTAQ1
NUDC
NUDCD2
PAGE2
PDLIM2
PEX5
PFKP
PGM2
POT1
RBKS
RECQL4
RGS3
RPSA
SBDS
STIP1
STUB1
SULT1C2
TAGLN
TBC1D10A
TBCD
TINF2
TOMM34
TRIM15
TRIM16
TRIM55
TRIM63
TUBB2A
TUBB4B
USP7
XRCC6
YWHAE
ZFP36L1
ZNF790
84 interacting genes:
ACD
AHSG
AKT1
ANGPTL4
ANP32B
ARL6IP1
BCAS3
BEX1
BLM
CCDC6
CCNE1
CCNE2
CDC34
CEBPD
CUL1
DISC1
DVL1
EBNA1BP2
EXT1
EZH2
FANCC
FBP1
FBP2
FBXO45
GALNT12
GATA2
GATA3
GFI1
GLMN
HEMGN
HEY1
HIPK2
HNRNPK
HRAS
IGFBP3
IL24
JUN
KLF10
KLF5
KMT2D
LINGO1
MAP2K1
MAPK3
MMS22L
MYB
MYC
MYCN
NANS
NOTCH1
NOTCH4
NPM1
PLK1
PPARGC1A
PPP3R2
PRKN
PSEN1
PTPN11
RACK1
RFLNA
SCGB3A1
SEC61B
SHC1
SHOC2
SHPRH
SIK2
SKP1
SMAD1
SOX9
SP7
SPI1
SREBF1
STAT3
STAT5A
STOML1
STYX
SUMF2
TGFB1
TMOD1
TP53
TSC22D4
USP9X
WDR97
XPA
ZNF510
Entrez ID
65057
55294
HPRD ID
12417
05888
Ensembl ID
ENSG00000102977
ENSG00000109670
Uniprot IDs
A0A590TQL1
Q96AP0
G0Z2K0
Q969H0
S4R3U4
PDB IDs
2I46
5H65
5I2X
5I2Y
5UN7
5XYF
2OVP
2OVQ
2OVR
5IBK
5V4B
Enriched GO Terms of Interacting Partners
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