BCL11B and CBX5

Number of citations of the paper that reports this interaction (PubMedID 12692243)
42

Data Source:
HPRD (in vitro, in vivo)

		BCL11B	CBX5
Description		BAF chromatin remodeling complex subunit BCL11B	chromobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Neuron Projection	Histone Deacetylase Complex Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding DNA-binding Transcription Factor Binding
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Hematopoietic Stem Cell Migration Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive T Cell Selection Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Thymus Development Olfactory Bulb Axon Guidance Lymphoid Lineage Cell Migration Into Thymus	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated
Pathways			SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs			Copper
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Airway wall thickness ( 25517131) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic stiffness ( 22068335) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 22969067) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medial thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Posterior thalamic nuclei volume ( 34006833) Proximal colorectal cancer ( 33632709) Red blood cell count ( 32888494) Schizophrenia ( 28991256 25056061 29483656 30285260) Staphylococcus aureus infection ( 24847357) Systolic blood pressure night-to-day ratio in hypertension ( 29973135) Triglyceride levels in HIV infection ( 33109212) Waist circumference ( 34074324)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: BEGAIN C14orf132 CBX5 MBD3 MTA2 NR2F1 NR2F2 RBBP4 RBBP7 SP1 SUV39H1 WDR25	60 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FES FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		64919	23468
HPRD ID		05950	05131
Ensembl ID		ENSG00000127152	ENSG00000094916
Uniprot IDs		L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0	P45973 V9HWG0
PDB IDs			3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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