CBX5 and ZNF280C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CBX5	ZNF280C
Description		chromobox 5	zinc finger protein 280C
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	Nucleus
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Height ( 31562340) Reticulocyte count ( 32888494)
Interacting Genes		60 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FES FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	7 interacting genes: CBX1 CBX3 CBX5 GOLGA2 HOMEZ KRTAP10-6 TSPYL2
Entrez ID		23468	55609
HPRD ID		05131	06526
Ensembl ID		ENSG00000094916	ENSG00000056277
Uniprot IDs		P45973 V9HWG0	Q8ND82
PDB IDs		3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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