CBX5 and LAP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CBX5	LAP3
Description		chromobox 5	leucine aminopeptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	Nucleus Nucleoplasm Trans-Golgi Network Cytosol Focal Adhesion Midbody Extracellular Exosome
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding DNA-binding Transcription Factor Binding	Aminopeptidase Activity Carboxypeptidase Activity Protein Binding Metalloexopeptidase Activity Manganese Ion Binding Metalloaminopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated	Proteolysis
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs		Copper	Leucine Phosphonic Acid (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid Zofenoprilat
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		60 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FES FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	14 interacting genes: APP BANP CBX3 CBX5 FXR1 LIG4 MAPRE3 OGT PIH1D2 PIK3R3 TAB1 USF1 ZNF76 ZYX
Entrez ID		23468	51056
HPRD ID		05131	07516
Ensembl ID		ENSG00000094916	ENSG00000002549
Uniprot IDs		P45973 V9HWG0	P28838
PDB IDs		3FDT 3I3C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?