SLC13A3 and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC13A3	CYB5R3
Description		solute carrier family 13 member 3	cytochrome b5 reductase 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Dicarboxylic Acid Transmembrane Transporter Activity Protein Binding Citrate Transmembrane Transporter Activity Alpha-ketoglutarate Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity High-affinity Sodium:dicarboxylate Symporter Activity Sodium:dicarboxylate Symporter Activity Glutathione Transmembrane Transporter Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding Nitrite Reductase (NO-forming) Activity NAD Binding FAD Binding
	Biological Process	Sodium Ion Transport Dicarboxylic Acid Transport Alpha-ketoglutarate Transport Citrate Transport Glutathione Transmembrane Transport Succinate Transmembrane Transport Anion Transmembrane Transport Transport Across Blood-brain Barrier	Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation
Pathways		Sodium-coupled sulphate, di- and tri-carboxylate transporters	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Chronic kidney disease ( 24351856) Glomerular filtration rate ( 24351856) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Serum metabolite levels ( 33031748) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Initial pursuit acceleration ( 29064472)
Interacting Genes		11 interacting genes: ARL13B CISD2 CREB3L1 CYB5R3 ERGIC3 FAM209A GPX8 LEUTX LMNA RMDN3 TSC2	68 interacting genes: ADAM33 AGTRAP AIG1 ALG8 AQP6 ARSA ASGR1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAS1 GAST GPR152 GRM2 HBG2 HSD17B13 L3MBTL2 LAPTM5 LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PNLIPRP1 REEP4 RPS6KB1 SBF1 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C TUBGCP6 UBIAD1 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 XPNPEP3 ZDHHC15
Entrez ID		64849	1727
HPRD ID		10450	08942
Ensembl ID		ENSG00000158296	ENSG00000100243
Uniprot IDs		B4DF27 Q8WWT9	P00387
PDB IDs			1M91 1UMK
Enriched GO Terms of Interacting Partners?
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