GMCL1 and APLF

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		GMCL1	APLF
Description		germ cell-less 1, spermatogenesis associated	aprataxin and PNKP like factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Matrix	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Germ Cell Development Spermatogenesis	Single Strand Break Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 30061737 29892015) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)	Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		100 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL C5orf60 CCDC13 CCDC25 CDC37 CFAP410 CHIC2 CIB3 CLK2 CUL3 CYP26B1 EHHADH ELOA EMD EXOC3 FAM167A FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GMCL2 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 XAGE3 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250	7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		64395	200558
HPRD ID		13587	09848
Ensembl ID		ENSG00000087338	ENSG00000169621
Uniprot IDs		Q53SE7 Q96IK5	Q8IW19
PDB IDs			2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ
Enriched GO Terms of Interacting Partners?
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