APLF and IRX5

Number of citations of the paper that reports this interaction (PubMedID 17396150)
68

Data Source:
HPRD (in vitro)

		APLF	IRX5
Description		aprataxin and PNKP like factor	iroquois homeobox 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break	Chromatin Nucleus
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Vitamin D Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Single Strand Break Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis	Regulation Of Transcription By RNA Polymerase II Visual Perception Gonad Development Neuron Differentiation Cell Development Embryonic Cranial Skeleton Morphogenesis Response To Stimulus
Pathways
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)	Aspartate aminotransferase levels ( 33547301) Dialysis-related mortality ( 21546767) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Refractive error ( 32231278) Social communication problems ( 24564958) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4	1 interacting genes: APLF
Entrez ID		200558	10265
HPRD ID		09848	08395
Ensembl ID		ENSG00000169621	ENSG00000176842
Uniprot IDs		Q8IW19	P78411
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ
Enriched GO Terms of Interacting Partners?
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