GPSM3 and MAPK7

Number of citations of the paper that reports this interaction (PubMedID 21516116)
114

Data Source:
BioGRID (two hybrid)

		GPSM3	MAPK7
Description		G protein signaling modulator 3	mitogen-activated protein kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Molecular_function Protein Binding GTPase Regulator Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Biological_process Positive Regulation Of Inflammatory Response Regulation Of Catalytic Activity Positive Regulation Of Cytokine Production Involved In Inflammatory Response	MAPK Cascade Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		G alpha (i) signalling events	ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs			Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Asthma ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Body mass index ( 31453325) Body mass index variance ( 31453325) Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163) Hip circumference ( 31453325) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease ( 30636644)
Interacting Genes		45 interacting genes: ACMSD ANKRD33 ASB15 BATF2 BMF C10orf82 C11orf45 C9orf57 CHRDL2 COA7 CTAG1A CTAG1B FAM86C1P FGFR3 GATAD2B GNAI1 GNAI2 GNAI3 HELT HIGD2B HRAS HSF2BP IQCE IVD KRTAP11-1 KRTAP13-3 KRTAP19-4 MAPK7 MBD3L1 MEOX2 NR0B2 P4HA3 PRR5 RIPK4 RSPO4 SPAG8 SPRY3 STXBP5L TADA2A TEX11 UFSP1 USHBP1 YWHAZ ZNF20 ZNF581	37 interacting genes: ACTN4 ADI1 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FLII FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K4 MAP2K5 MEF2A MEF2C MEF2D MFAP4 MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RASGRP1 RXRA SGK1 SH2D2A SREBF1 UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1
Entrez ID		63940	5598
HPRD ID		13605	03952
Ensembl ID		ENSG00000213654	ENSG00000166484
Uniprot IDs		A0A024RCP6 Q9Y4H4	A0A024QZ20 Q13164
PDB IDs			2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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