SCNN1A and SNX3

Number of citations of the paper that reports this interaction (PubMedID 18632802)
26

Data Source:
HPRD (in vivo)

		SCNN1A	SNX3
Description		sodium channel epithelial 1 subunit alpha	sorting nexin 3
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Exosome Sperm Principal Piece	Cytoplasm Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Extracellular Exosome
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Retromer Complex Binding
	Biological Process	Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport
Pathways		Stimuli-sensing channels	WNT ligand biogenesis and trafficking Ub-specific processing proteases
Drugs		Triamterene Amiloride	S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000) Spleen volume ( 34128465)
Interacting Genes		18 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L NPC2 SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2	12 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RAB7A RPRM SCNN1A STX11 TSC22D2 USP10 VPS35
Entrez ID		6337	8724
HPRD ID		02575	09333
Ensembl ID		ENSG00000111319	ENSG00000112335
Uniprot IDs		P37088	O60493
PDB IDs		2M3O 6BQN 6WTH	2MXC 2YPS 5F0J 5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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